Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:

It was only from the nineties nevertheless, when nanotechnology had State-of-the-art to some stage in which one molecules could possibly be manipulated, that the main experimental gadgets commenced to appear.

Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins

2007, initially real-time detection of strand Trade in homologous recombination by RecA; discovery of the low persistence size of finishes of microtubules; and resolved the system of biosensing with carbon nanotubes

We establish place-of-care diagnostics check of neglected tropical diseases in just source-constrained settings, dependant on Crspr/Cas9 detecting of pathogen’s DNA in overall body fluids.

The coiled-coil of your human Rad50 DNA mend protein consists of unique segments of enhanced flexibility

We condition micro organism into kinds that deviate from their normal phenotype. Especially, I will show our power to condition Dwell E. coli microorganisms into novel shapes which include rectangles, squares, triangles and circles.

2000, discovery that nanotubes can carry remarkable substantial current densities; settled the controversial difficulty of electronic transport by way of DNA molecules by measurements of insulating actions at the single molecule degree; and demonstration of the AFM technique for single-molecule manipulation of nanotubes

In 1993, as a young and eager affiliate professor at Delft College of Technologies, I had to begin with concentrated the study initiatives of my team on measuring the electrical conductance of only cees dekker one conducting-polymer molecule. Inside two a long time, we experienced established a device by which an individual wire of the phthalocyaninepolysiloxane polymer was related between two closely spaced metal nanoelectrodes.

Resolving the move sizing in condensin-pushed DNA loop extrusion identifies ATP binding given that the action-making system

An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes

A lot of new phenomena were discovered, and he and his exploration group founded a leading posture In this particular field of exploration. Dekker and his analysis team identified new physics of nanotubes and explored the feasibility of molecular electronics. In 1998, they have been the first to develop a transistor according to one nanotube molecule.

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It was an incredibly attention-grabbing time, in the course of which I gained a lot of help from Delft College of Technological know-how, exactly where I used to be a professor at enough time, And that i begun a number of collaborations with molecular biologists. That assisted me study lots.’